Based on explosion impact dynamics, mechanism of multi-layers materials structure for blast-resistant that is compounded by reinforced concrete, porous plastic, cellular concrete and steel plate is investigated under explosion wave and impact loading. Explosion wave propagation and dynamic load in multi-layers structure included air, concrete, porous materials are explored. In the near range, the failure of compound structure is studied by coupling analysis of shock wave and the flyer. As one of meshless methods, MPM (material point method) is applied to three-dimension numerical simulation, by which deformation and damage of multi-layers structure for blast-resistant are calculated. Furthermore, some kinds of multi-layers structure which are used to explosion impact experiments are designed and constructed. Dynamic stress, strain, impact load and damped process for multi-layers materials are test. Theory model and the result of numerical simulation can be verified by comparison with experimental data. The combination of theoretical analysis, numerical simulation and experimental verification is a main feature of the project. Reliable theory model and experimental data can be provided for the design optimization of blast-resistant structure.